KEGG T01001: 51135

Homo sapiens (human): 51135

Entry

51135             CDS       T01001

Symbol

IRAK4, IMD67, IPD1, IRAK-4, NY-REN-64, REN64

Name

(RefSeq) interleukin 1 receptor associated kinase 4

K04733

interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04064

NF-kappa B signaling pathway

hsa04620

Toll-like receptor signaling pathway

hsa04621

NOD-like receptor signaling pathway

hsa04722

Neurotrophin signaling pathway

hsa04936

Alcoholic liver disease

hsa05130

Pathogenic Escherichia coli infection

hsa05132

Salmonella infection

hsa05133

Pertussis

hsa05135

Yersinia infection

hsa05140

Leishmaniasis

hsa05142

Chagas disease

hsa05145

Toxoplasmosis

hsa05152

Tuberculosis

hsa05161

Hepatitis B

hsa05162

Measles

hsa05164

Influenza A

hsa05168

Herpes simplex virus 1 infection

hsa05169

Epstein-Barr virus infection

hsa05170

Human immunodeficiency virus 1 infection

hsa05171

Coronavirus disease - COVID-19

hsa05417

Lipid and atherosclerosis

Network

nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06180  Pathogenic Escherichia coli
nt06182  Shigella
nt06183  Yersinia
nt06211  Other MAPK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06526  MAPK signaling

Element

N00186

IL1-IL1R-p38 signaling pathway

N00188

IL1-IL1R-JNK signaling pathway

N00435

TLR1/2/4-NFKB signaling pathway

N00438

TLR2/4-MAPK signaling pathway

N00690

TLR7/9-IRF7 signaling pathway

N01543

TLR7/8/9-IRF5 signaling pathway

N01566

TLR5-NFKB signaling pathway

Disease

H00096

Defects of toll-like receptor signaling

Drug target

Emavusertib (DG03236):

D12411 D12412 D12532 D12533 D12538 D12539

Zimlovisertib:

D12167

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    51135 (IRAK4)
   04064 NF-kappa B signaling pathway
    51135 (IRAK4)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    51135 (IRAK4)
   04621 NOD-like receptor signaling pathway
    51135 (IRAK4)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    51135 (IRAK4)
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    51135 (IRAK4)
   05161 Hepatitis B
    51135 (IRAK4)
   05171 Coronavirus disease - COVID-19
    51135 (IRAK4)
   05164 Influenza A
    51135 (IRAK4)
   05162 Measles
    51135 (IRAK4)
   05168 Herpes simplex virus 1 infection
    51135 (IRAK4)
   05169 Epstein-Barr virus infection
    51135 (IRAK4)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    51135 (IRAK4)
   05132 Salmonella infection
    51135 (IRAK4)
   05135 Yersinia infection
    51135 (IRAK4)
   05133 Pertussis
    51135 (IRAK4)
   05152 Tuberculosis
    51135 (IRAK4)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    51135 (IRAK4)
   05140 Leishmaniasis
    51135 (IRAK4)
   05142 Chagas disease
    51135 (IRAK4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    51135 (IRAK4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    51135 (IRAK4)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    51135 (IRAK4)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     51135 (IRAK4)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: TKL group
  IRAK family
   51135 (IRAK4)

SSDB

Motif

Pfam:

PK_Tyr_Ser-Thr Pkinase Pkinase_fungal Haspin_kinase Death RecA_C

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

12:43758951..43789541

AA seq 460 aa
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

NT seq 1383 nt +upstreamnt +downstreamnt
atgaacaaacccataacaccatcaacatatgtgcgctgcctcaatgttggactaattagg
aagctgtcagattttattgatcctcaagaaggatggaagaagttagctgtagctattaaa
aaaccatctggtgatgatagatacaatcagtttcacataaggagatttgaagcattactt
caaactggaaaaagtcccacttctgaattactgtttgactggggcaccacaaattgcaca
gttggtgatcttgtggatcttttgatccaaaatgaattttttgctcctgcgagtcttttg
ctcccagatgctgttcccaaaactgctaatacactaccttctaaagaagctataacagtt
cagcaaaaacagatgcctttctgtgacaaagacaggacattgatgacacctgtgcagaat
cttgaacaaagctatatgccacctgactcctcaagtccagaaaataaaagtttagaagtt
agtgatacacgttttcacagtttttcattttatgaattgaagaatgtcacaaataacttt
gatgaacgacccatttctgttggtggtaataaaatgggagagggaggatttggagttgta
tataaaggctacgtaaataacacaactgtggcagtgaagaagcttgcagcaatggttgac
attactactgaagaactgaaacagcagtttgatcaagaaataaaagtaatggcaaagtgt
caacatgaaaacttagtagaactacttggtttctcaagtgatggagatgacctctgctta
gtatatgtttacatgcctaatggttcattgctagacagactctcttgcttggatggtact
ccaccactttcttggcacatgagatgcaagattgctcagggtgcagctaatggcatcaat
tttctacatgaaaatcatcatattcatagagatattaaaagtgcaaatatcttactggat
gaagcttttactgctaaaatatctgactttggccttgcacgggcttctgagaagtttgcc
cagacagtcatgactagcagaattgtgggaacaacagcttatatggcaccagaagctttg
cgtggagaaataacacccaaatctgatatttacagctttggtgtggttttactagaaata
ataactggacttccagctgtggatgaacaccgtgaacctcagttattgctagatattaaa
gaagaaattgaagatgaagaaaagacaattgaagattatattgataaaaagatgaatgat
gctgattccacttcagttgaagctatgtactctgttgctagtcaatgtctgcatgaaaag
aaaaataagagaccagacattaagaaggttcaacagctgctgcaagagatgacagcttct
taa

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